The 6 Best Boutique Hotels in St. Louis [2025]

The city of St. Louis can be found along the Mississippi River. It is the second-largest city in the state of Missouri and is famous for its iconic Gateway Arch, built in the 1960s. Known for its barbecue restaurants and amazing blues music history, St. Louis is a great city to explore.

Visitors to the city will find many ultra-comfortable boutique hotels in St. Louis.

The Best Boutique Hotels in St. Louis

Angad Arts Hotel

Price: From $134

The Angad Arts Hotel can be found in St. Louis’ history-filled Grand Center Arts District. This boutique option takes inspiration from its surroundings and provides guests with a one-of-a-kind experience.

Those who wish to stay at the hotel are advised to find their room based on creativity and mood color. While browsing the available accommodation options, prospective guests should choose the color that most speaks to them and what they wish to feel.

The selections are red for empowerment, blue for freedom, green for rejuvenation, and yellow for curiosity. The creativity-filled rooms include amenities like a comfortable work desk, a velvet club chair perfect for lounging, luxury bath products, custom artwork, a flat-screen with DirecTV, soft bathrobes and cotton towels, and a safe.

The Cheshire

Price: From $149

The Cheshire is a quirky British-themed hotel that brings international appeal to St. Louis. It can be found near Washington University and Forest Park. Designed with Tudor architecture and lattice-style glass windows, the Cheshire can be easily recognized by the British flag at the entrance.

The welcoming lobby has a country manor aesthetic with 18th-century antiques and a wood-burning stone fireplace. Each guest room and suite is named after a British poet, writer, or playwright.

Contemporary comforts are peppered into every space. Each room has a flat-screen TV, iPod dock, luxurious bedding, and cozy duvets. The hotel has a trendy pool with poolside cabanas and a bar that serves food and drinks.

Coffee and tea service is available 24/7, and guests are treated to fresh breakfast daily at the charming Fox & Hounds Tavern.

The Last Hotel

Price: From $179

The Last Hotel can be found in downtown St. Louis in what used to be the historical International Shoe Co. building, which originally opened in 1909. This stylish boutique hotel preserves many original features, like stone carvings, terrazzo floors, and Art Deco and Neoclassical accents.

The Last Hotel seamlessly blends history with contemporary convenience. Accommodation options include king and queen guest rooms, suites, and VIP suites. Each room has a minibar, original barrel ceiling, designer boutique linens, a workspace with a writing desk, and a Power Port Box to help with all electronic devices.

The opulent VIP suites add designer bath products from CO Bigelow, an oversized bathroom, and a walk-in shower with custom subway tiles. The Last Hotel has an on-site Italian steakhouse restaurant, as well as a rooftop lounge.

The Lodge at Grant’s Trail

Price: From $120

The Lodge at Grant’s Trail offers unique, rustic-chic accommodation in St. Louis. Removed from the frenzy of the city but with great downtown access, The Lodge offers a rugged version of luxury to guests. Known for its coziness and delicious complimentary breakfasts, this boutique hotel is a great location for ultimate relaxation.

Accommodation options at The Lodge at Grant’s Trail include presidential suites and specialty rooms with specific design themes. Each room has a fireplace, a full bathroom with a tub and shower combo, and a satellite TV.

On top of that, each space has its own defining features that set it apart from the others. The presidential suites are named after Abraham Lincoln, his wife Mary Lincoln, and George Washington.

The specialty rooms feature themes like Safari, Rockbridge, Mississippi, Alaska, Christmas, and Frontier. Each is a delight to discover.

Moonrise Hotel

Price: From $164

A quirky space-themed boutique hotel, the Moonrise Hotel can be found in St. Louis’ Delmar Loop District, right next to the Pageant concert hall. Each room at the Moonrise Hotel is full of space-themed whimsy and boutique luxury.

Amenities include Serta beds, moon-themed artwork, premium linens, custom furnishings, a work area with desk and executive chair, a plasma TV, a radio alarm clock, a Cuisinart coffee maker with Starbucks coffee and Stash teas, and a minifridge. The bathrooms feature a walk-in shower or bathtub with Symmons Rain Shower and designer bath products by Aveda.

In addition, the hotel has a 24-hour fitness center, a business center with state-of-the-art tools, a rooftop garden bar, and an award-winning on-site restaurant.

The rooftop Twilight Room is a perfect space for bigger events like weddings or private parties.

Seven Gables Inn

Price: From $127

Found right on the western outskirts of St. Louis in Clayton, visitors can find the luxurious and peaceful Seven Gables Inn. Despite having great access to the city, the property is an oasis in a thriving community of creators.

The Seven Gables Inn provides a great location for guests to unwind and escape the routine full of old-world elegance and modern comforts. Each room at the inn has complimentary Wi-Fi, a large flat-screen TV with HBO channels, stylish hardwood floors, a clothing steamer, and a coffee maker. The bathroom features a Toto washlet toilet, luxurious bath products from Johnathan Adler, and comfortable robes and slippers.

A hot and cold complimentary breakfast is served every day as a buffet. In addition, there is an on-site restaurant and bar, as well as a meeting or event space ideal for business travelers.

Final Thoughts

St. Louis has a rich history, represented by many cultural landmarks for visitors to explore. From the Gateway Arch to the Cathedral Basilica, there is much to see. The St. Louis Zoo, Forest Park, and Art Museum are also top-rated attractions in the city.